What is GRALISE?
is a prescription medicine for people 18 years and older to treat pain from damaged nerves (neuropathic pain) that follows healing of shingles (a painful rash that comes after herpes zoster infection).1
GRALISE is not interchangeable with other gabapentin products.1
GRALISE contains gabapentin, which has been used for years to treat after-shingles pain (postherpetic neuralgia, or PHN). However, GRALISE is different from other gabapentin products because you only need to take it once a day to get the benefit of 24-hour
GRALISE may not work for everyone. Talk with your doctor about whether GRALISE is right for you.
Why is once-daily oral dosing important?
The once-daily oral dosing for GRALISE — 3 tablets taken with the evening meal — comes with a number of advantages:
- It's easier to keep track of your treatment because you take it just once a day with your
- GRALISE delivers long-lasting pain control, and because it's taken with the evening meal, the levels of medication in your system stay high throughout the night3
- The dosing schedule helps you stay on GRALISE once you start using it4
- Take GRALISE with the evening meal. If it is taken on an empty stomach the drug may not work as well2
Do not take GRALISE if you are allergic to gabapentin or any of the ingredients in GRALISE. See the end of the Medication Guide
for a complete list of ingredients in GRALISE.
Like other antiepileptic drugs, gabapentin, the active ingredient in GRALISE, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
GRALISE is a prescription medicine used in adults, 18 years and older, to treat pain from damaged nerves (neuropathic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection).
Do not take GRALISE if you are allergic to gabapentin or any of the ingredients in GRALISE.
Do not change your dose or stop taking GRALISE without talking with your healthcare provider.
If you stop taking GRALISE suddenly, you may experience side effects. Talk with your healthcare provider about how to stop GRALISE slowly.
Like other antiepileptic drugs, gabapentin, the active ingredient in GRALISE, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. However, it is not known if GRALISE is safe and effective in people with seizure problems (epilepsy). Therefore, GRALISE should not be used in place of other gabapentin products.
It is not known if GRALISE is safe and effective in children under 18 years of age with postherpetic pain.
Before taking GRALISE, tell your healthcare provider if you:
- have or have had depression, mood problems or suicidal thoughts or behavior
- have seizures
- have kidney problems or get kidney dialysis
- are pregnant or plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking GRALISE.
- are breastfeeding or plan to breastfeed. GRALISE can pass into your breast milk.
Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins or herbal supplements. Taking GRALISE with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.
Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking GRALISE without first talking to your healthcare provider. Taking GRALISE with alcohol or medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse.
Do not operate heavy machines or do other dangerous activities until you know how GRALISE affects you. GRALISE can slow your thinking and motor skills.
The most common side effect of GRALISE is dizziness. Tell your healthcare provider about any side effect that bothers you or that does not go away. This is not the only possible side effect of GRALISE. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report negative side effects to Depomed at 1-866-458-6389.
GRALISE [prescribing information]. Newark, CA: Depomed Inc.; December 2012. 2.
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a694007.html. Accessed September 15, 2011. 3.
Data on file, Depomed Inc. 4.
Saini S, Schoenfield P, Kaulback K, et al. Effect of medication dosing frequency on adherence in chronic diseases. Am J Manag Care.
Advisory Committee on Immunization Practices. Prevention of herpes zoster. MMWR
Please see full Prescribing Information and Medication Guide.