Getting Started With GRALISE
GRALISE® is the only once-a-day, oral medication for after-shingles pain that provides you with 24-hour pain control.1,2 GRALISE works in a way that allows you to reach an effective dose in just 2 weeks. Plus, evening dosing allows for a low rate of side effects.1

How should I take GRALISE?
You should take GRALISE exactly as prescribed. Your doctor will tell you how much GRALISE to take and when to take it.1
  • Take GRALISE with food one time each day with your evening meal
  • Do not change your dose or stop taking GRALISE without talking with your doctor. If you stop taking GRALISE suddenly, you may experience side effects. Talk with your doctor about how to stop GRALISE slowly
  • Take GRALISE tablets whole. Do not split, crush, or chew GRALISE tablets before swallowing
  • Your doctor may change your dose of GRALISE. Do not change your dose of GRALISE without talking to your doctor
  • If you miss a dose, take it as soon as you remember with food. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take 2 doses at the same time
  • If you take too much GRALISE, call your doctor or poison control center, or go to the nearest emergency room right away
  • If you are taking an antacid containing aluminum hydroxide and magnesium hydroxide, it is recommended that GRALISE be taken at least 2 hours following administration of the antacid
Starting therapy with GRALISE
If you're new to GRALISE, your doctor will want to begin your treatment gradually. This process is called titration, and it helps make sure that you start getting an effective dose of GRALISE as quickly as possible while reducing the risk of any side effects. An effective dose of GRALISE can be reached in just 2 weeks.1

Usual titration schedule for starting GRALISE
GRALISE titration schedule
The GRALISE Starter Pack can help get you to an effective dose quickly
GRALISE Starter Pack
If your doctor prescribes GRALISE to treat after-shingles pain, your first prescription may be the GRALISE Starter Pack. The Starter Pack includes1:
  • Easy to follow, day-by-day dosing instructions to help you build up (titrate) to an effective dose in just 2 weeks
  • 2 weeks worth of medication for your titration period (provided as 300 mg and 600 mg tablets) and 2 weeks worth of your full GRALISE dose (three 600 mg tablets per day)
Tell your healthcare provider if you have kidney problems, as dosage adjustments may be necessary.
Indication and Usage
GRALISE is a prescription medicine used in adults, 18 years and older, to treat pain from damaged nerves (neuropathic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection).

Important Safety Information
Do not take GRALISE if you are allergic to gabapentin or any of the ingredients in GRALISE.

Do not change your dose or stop taking GRALISE without talking with your healthcare provider. If you stop taking GRALISE suddenly, you may experience side effects. Talk with your healthcare provider about how to stop GRALISE slowly.

Like other antiepileptic drugs, gabapentin, the active ingredient in GRALISE, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. However, it is not known if GRALISE is safe and effective in people with seizure problems (epilepsy). Therefore, GRALISE should not be used in place of other gabapentin products.

It is not known if GRALISE is safe and effective in children under 18 years of age with postherpetic pain.

Before taking GRALISE, tell your healthcare provider if you:
  • have or have had depression, mood problems or suicidal thoughts or behavior
  • have seizures
  • have kidney problems or get kidney dialysis
  • are pregnant or plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking GRALISE.
  • are breastfeeding or plan to breastfeed. GRALISE can pass into your breast milk.
Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins or herbal supplements. Taking GRALISE with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking GRALISE without first talking to your healthcare provider. Taking GRALISE with alcohol or medicines that cause sleepiness or dizziness may make your sleepiness or dizziness worse.

Do not operate heavy machines or do other dangerous activities until you know how GRALISE affects you. GRALISE can slow your thinking and motor skills.

The most common side effect of GRALISE is dizziness. Tell your healthcare provider about any side effect that bothers you or that does not go away. This is not the only possible side effect of GRALISE. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088. You may also report negative side effects to Depomed at 1-866-458-6389.

References: 1. GRALISE [prescribing information]. Newark, CA: Depomed Inc.; December 2012. 2. Data on file. Depomed Inc. 3. Postherpetic neuralgia. Accessed May 22, 2012. 4. Gabapentin. Accessed September 15, 2011.

Please see full Prescribing Information and Medication Guide.
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