once-daily management
for PHN1

Not an actual patient.

What is GRALISE?

GRALISE is a prescription medicine used to treat pain after shingles, or postherpetic neuralgia (PHN).1 Once-daily dose of GRALISE, taken with your evening meal, can help manage PHN through the night and day.1234

What makes GRALISE different?

Other treatments with gabapentin empty from the stomach quickly, but GRALISE features technology to optimize delivery into the small intestines where the medicine can be absorbed.1245

Why only once a day?

The delivery technology of GRALISE allows for a gradual release of medication. When taken with the evening meal, GRALISE is designed to release gradually into your body while you sleep.1245


  1. GRALISE. Prescribing information. Almatica Pharma LLC; 2020.
  2. Sang CN, Sathyanarayana R, Sweeney M, DM-1796 Study Investigators. Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN). Clin J Pain. 2013;29(4):281-288.
  3. Mehta N, Bucior I, Bujanover S, Shah R, Gulati A. Relationship between pain relief, reduction in pain-associated sleep interference, and overall impression of improvement in patients with postherpetic neuralgia treated with extended-release gabapentin. Health Qual Life Outcomes. 2016;14:54.
  4. Argoff CE, Chen C, Cowles VE. Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview. Expert Opin Drug Deliv. 2012;9(9):1147-1160.
  5. Chen C, Cowles VE, Hou E. Pharmacokinetics of gabapentin in a novel gastric-retentive extended-release formulation: comparison with an immediate-release formulation and effect of dose escalation and food. J Clin Pharmacol. 2011;51(3):346-358.
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Most patients pay as little as $20*

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*Applies to commercially insured patients. Individual costs may vary. Program eligibility and restrictions apply.