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Take GRALISE exactly as your healthcare provider tells you.

GRALISE is taken once daily, at the same time each day, and works best with the evening meal.1234 Taking GRALISE at night with your evening meal helps your body absorb the medication.134

Important for you to know:

  • Take GRALISE with food 1 time each day with a high-fat evening meal1
  • Take GRALISE tablets whole. Do not split, crush, or chew GRALISE tablets before you swallow them1
  • Your healthcare provider may change your dose of GRALISE. Do not change your dose without talking to your healthcare provider1
  • To help manage potential side effects, do not change your dose or stop taking GRALISE without talking to your healthcare provider1
  • If you miss a dose, take it with food as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take 2 doses at the same time1
  • If you take too much GRALISE, call your healthcare provider or poison control center, or go to the nearest emergency room right away
  • If you are taking an antacid that contains aluminum hydroxide and magnesium hydroxide, it is recommended that GRALISE be taken at least 2 hours after you take the antacid1
  • When taking GRALISE with other medications, such as opioids, there is the potential for drug-to-drug interaction. Always ask your doctor before combining GRALISE with other medications1

Have questions about GRALISE? Ask your doctor.


  1. GRALISE. Prescribing information. Almatica Pharma LLC; 2020.
  2. Sang CN, Sathyanarayana R, Sweeney M, DM-1796 Study Investigators. Gastroretentive gabapentin (G-GR) formulation reduces intensity of pain associated with postherpetic neuralgia (PHN). Clin J Pain. 2013;29(4):281-288.
  3. Argoff CE, Chen C, Cowles VE. Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview. Expert Opin Drug Deliv. 2012;9(9):1147-1160.
  4. Chen C, Cowles VE, Hou E. Pharmacokinetics of gabapentin in a novel gastric-retentive extended-release formulation: comparison with an immediate-release formulation and effect of dose escalation and food. J Clin Pharmacol. 2011;51(3):346-358.
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